Effects of nucleoid-associated proteins on bacterial chromosome structure and gene expression

被引：230

作者：

Browning, Douglas F. ^{[2
]}

Grainger, David C. ^{[3
]}

Busby, Stephen J. W. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Sch Immun & Infect, Birmingham B15 2TT, W Midlands, England

[3] Univ Warwick, Dept Biol Sci, Coventry CV4 7AL, W Midlands, England

来源：

CURRENT OPINION IN MICROBIOLOGY | 2010年 / 13卷 / 06期

基金：

英国惠康基金;

关键词：

ESCHERICHIA-COLI CHROMOSOME; GENOME-WIDE ANALYSIS; H-NS; MYCOBACTERIUM-TUBERCULOSIS; TRANSCRIPTIONAL REGULATION; OCCUPANCY LANDSCAPE; BINDING-PROTEIN; HIGH-AFFINITY; FIS PROTEIN; IN-VITRO;

D O I：

10.1016/j.mib.2010.09.013

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Bacterial nucleoid-associated proteins play a key role in the organisation, replication, segregation, repair and expression of bacterial chromosomes. Here, we review some recent progress in our understanding of the effects of these proteins on DNA and their biological role, focussing mainly on Escherichia coli and its chromosome. Certain nucleoid-associated proteins also regulate transcription initiation at specific promoters, and work in concert with dedicated transcription factors to regulate gene expression in response to growth phase and environmental change. Some specific examples, involving the E. coli IHF and Fis proteins, that illustrate new principles, are described in detail.

引用

页码：773 / 780

页数：8

共 61 条

[1] Twelve species of the nucleoid-associated protein from Escherichia coli -: Sequence recognition specificity and DNA binding affinity [J].

Azam, TA ;

Ishihama, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (46) :33105-33113

[2] Growth phase-dependent variation in protein composition of the Escherichia coli nucleoid [J].

Azam, TA ;

Iwata, A ;

Nishimura, A ;

Ueda, S ;

Ishihama, A .

JOURNAL OF BACTERIOLOGY, 1999, 181 (20) :6361-6370

[3] A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL [J].

Basu, Debashree ;

Khare, Garima ;

Singh, Shashi ;

Tyagi, Anil ;

Khosla, Sanjeev ;

Mande, Shekhar C. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (15) :4944-4954

[4] Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU [J].

Berger, Michael ;

Farcas, Anca ;

Geertz, Marcel ;

Zhelyazkova, Petya ;

Brix, Klaudia ;

Travers, Andrew ;

Muskhelishvili, Georgi .

EMBO REPORTS, 2010, 11 (01) :59-64

[5] Regulation by Nucleoid-Associated Proteins at the Escherichia coli nir Operon Promoter [J].

Browning, Douglas F. ;

Cole, Jeffrey A. ;

Busby, Stephen J. W. .

JOURNAL OF BACTERIOLOGY, 2008, 190 (21) :7258-7267

[6] Down-Regulation of the Escherichia coli K-12 nrf Promoter by Binding of the NsrR Nitric Oxide-Sensing Transcription Repressor to an Upstream Site [J].

Browning, Douglas F. ;

Lee, David J. ;

Spiro, Stephen ;

Busby, Stephen J. W. .

JOURNAL OF BACTERIOLOGY, 2010, 192 (14) :3824-3828

[7] DNA sampling: a method for probing protein binding at specific loci on bacterial chromosomes [J].

Butala, Matej ;

Busby, Stephen J. W. ;

Lee, David J. .

NUCLEIC ACIDS RESEARCH, 2009, 37 (05)

[8] Active Transcription of rRNA Operons Condenses the Nucleoid in Escherichia coli: Examining the Effect of Transcription on Nucleoid Structure in the Absence of Transertion [J].

Cabrera, Julio E. ;

Cagliero, Cedric ;

Quan, Selwyn ;

Squires, Catherine L. ;

Jin, Ding Jun .

JOURNAL OF BACTERIOLOGY, 2009, 191 (13) :4180-4185

[9] Genome-wide analysis of Fis binding in Escherichia coli indicates a causative role for A-/AT-tracts [J].

Cho, Byung-Kwan ;

Knight, Eric M. ;

Barrett, Christian L. ;

Palsson, Bernhard O. .

GENOME RESEARCH, 2008, 18 (06) :900-910

[10] Can the Protein Occupancy Landscape Show the Topologically Isolated Chromosomal Domains in the E. coli Genome?: An Exciting Prospect [J].

Cho, Byung-Kwan ;

Palsson, Bernhard O. .

MOLECULAR CELL, 2009, 35 (03) :255-256

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