Pd(II)-catalyzed cross-coupling of sp3 C-H bonds with sp2 and sp3 boronic acids using air as the oxidant

被引:432
作者
Wang, Dong-Hui [1 ]
Wasa, Masayuki [1 ]
Giri, Ramesh [1 ]
Yu, Jin-Quan [1 ]
机构
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
关键词
D O I
10.1021/ja801355s
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
O-Methyl hydroxamic acids, readily available from carboxylic acids, are found to be extremely reactive for P-C-H activation by Pd(OAC)(2). This reactivity is exploited to develop the first example of cross-coupling sp(3) C-H bonds with sp(3) boronic acids. Air was shown to be a suitable stoichiometric oxidant for the catalytic oxidative coupling reaction. A biologically active natural product is readily converted to its novel analogues through this coupling reaction.
引用
收藏
页码:7190 / +
页数:3
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