Remote mass spectrometric sampling of electrospray- and desorption electrospra-generated ions using an air ejector

被引：25

作者：

Dixon, R. Brent ^{[1
]}

Bereman, Michael S. ^{[1
]}

Muddiman, David C. ^{[1
]}

Hawkridge, Adam M. ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Chem, WM Keck FT ICR Mass Spectrometry Lab, Raleigh, NC 27695 USA

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY | 2007年 / 18卷 / 10期

关键词：

D O I：

10.1016/j.jasms.2007.07.024

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A commercial air ejector was coupled to an electrospray ionization linear ion trap mass spectrometer (LTQ) to transport remotely generated ions from both electrospray (ESI) and desorption electrospray ionization (DEST) sources. We demonstrate the remote analysis of a series of analyte ions that range from small molecules and polymers to polypeptides using the AE-LTQ interface. The details of the ESI-AE-LTQ and DESI-AE-LTQ experimental configurations are described and preliminary mass spectrometric data are presented.

引用

页码：1844 / 1847

页数：4

共 20 条

[11] Analysis of solids, liquids, and biological tissues using solids probe introduction at atmospheric pressure on commercial LC/MS instruments [J].

McEwen, CN ;

McKay, RG ;

Larsen, BS .

ANALYTICAL CHEMISTRY, 2005, 77 (23) :7826-7831

[12] Desorption electrospray ionization with a portable mass spectrometer:: in situ analysis of ambient surfaces [J].

Mulligan, CC ;

Talaty, N ;

Cooks, RG .

CHEMICAL COMMUNICATIONS, 2006, (16) :1709-1711

[13] Direct characterization of intact polypeptides by matrix-assisted laser desorption electrospray ionization quadrupole Fourier transform ion cyclotron resonance mass spectrometry [J].

Sampson, Jason S. ;

Hawkridge, Adam M. ;

Muddiman, David C. .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2007, 21 (07) :1150-1154

[14] Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) Fourier transform ion cyclotron resonance mass spectrometry [J].

Sampson, Jason S. ;

Hawkridge, Adam M. ;

Muddiman, David C. .

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2006, 17 (12) :1712-1716

[15] Electrospray-assisted laser desorption/ionization mass spectrometry for direct ambient analysis of solids [J].

Shiea, J ;

Huang, MZ ;

HSu, HJ ;

Lee, CY ;

Yuan, CH ;

Beech, I ;

Sunner, J .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2005, 19 (24) :3701-3704

[16] Amino acid clusters formed by sonic spray ionization [J].

Takats, Z ;

Nanita, SC ;

Cooks, RG ;

Schlosser, G ;

Vekey, K .

ANALYTICAL CHEMISTRY, 2003, 75 (06) :1514-1523

[17] Mass spectrometry sampling under ambient conditions with desorption electrospray ionization [J].

Takáts, Z ;

Wiseman, JM ;

Gologan, B ;

Cooks, RG .

SCIENCE, 2004, 306 (5695) :471-473

[18] Ambient mass spectrometry using desorption electrospray ionization (DESI):: instrumentation, mechanisms and applications in forensics, chemistry, and biology [J].

Takáts, Z ;

Wiseman, JM ;

Cooks, RG .

JOURNAL OF MASS SPECTROMETRY, 2005, 40 (10) :1261-1275

[19] Gentle protein ionization assisted by high-velocity gas flow [J].

Yang, PX ;

Cooks, RG ;

Ouyang, Z ;

Hawkridge, AM ;

Muddiman, DC .

ANALYTICAL CHEMISTRY, 2005, 77 (19) :6174-6183

[20] Incorporation of a venturi device in electrospray ionization [J].

Zhou, L ;

Yue, BF ;

Dearden, DV ;

Lee, ED ;

Rockwood, AL ;

Lee, ML .

ANALYTICAL CHEMISTRY, 2003, 75 (21) :5978-5983

← 1 2 →