Glycan arrays: biological and medical applications

被引：121

作者：

Liang, Pi-Hui ^{[1
,2
]}

Wu, Chung-Yi ^{[2
]}

Greenberg, William A. ^{[1
]}

Wong, Chi-Huey ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Acad Sinica, Genom Res Ctr, Taipei 11529, Taiwan

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2008年 / 12卷 / 01期

关键词：

D O I：

10.1016/j.cbpa.2008.01.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carbohydrates and their conjugates are involved in various biological events, including viral and bacterial infection, the immune response, differentiation and development, and the progression of tumor cell metastasis. Glycan arrays are a new technology that has enabled the high-sensitivity and rapid analysis carbohydrate-protein interaction and contribute to significant advances in glycomics. Glycan arrays use a minute amount of materials and can be used for high-throughput profiling and quantitative analysis and provide information for the development of carbo hydrate-based vaccines and new drug discovery.

引用

页码：86 / 92

页数：7

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