Charge and dielectric effects of biomolecules on electrical characteristics of nanowire FET biosensors

被引：20

作者：

Ahn, Jae-Hyuk ^{[1
]}

Choi, Sung-Jin ^{[2
]}

Im, Maesoon ^{[3
,4
]}

Kim, Sungho ^{[5
,6
]}

Kim, Chang-Hoon ^{[7
]}

Kim, Jee-Yeon ^{[7
]}

Park, Tae Jung ^{[8
]}

Lee, Sang Yup ^{[9
,10
]}

Choi, Yang-Kyu ^{[7
]}

机构：

[1] Kwangwoon Univ, Dept Elect Engn, Seoul 01897, South Korea

[2] Kookmin Univ, Sch Elect Engn, 77 Jeongneung Ro, Seoul 02707, South Korea

[3] Henry Ford Hlth Syst, Dept Ophthalmol, 1 Ford Pl, Detroit, MI 48202 USA

[4] Wayne State Univ, Dept Anat & Cell Biol, Sch Med, 540 East Canfield St, Detroit, MI 48201 USA

[5] Wayne State Univ, Dept Elect & Comp Engn, Coll Engn, 5050 Anthony Wayne Dr, Detroit, MI 48202 USA

[6] Sejong Univ, Dept Elect Engn, Seoul 05006, South Korea

[7] Korea Adv Inst Sci & Technol, Sch Elect Engn, 291 Daehak Ro, Daejeon 34141, South Korea

[8] Chung Ang Univ, Dept Chem, 84 Heukseok Ro, Seoul 06974, South Korea

[9] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Ctr Syst & Synthet Biotechnol,Inst BioCentury, BioProc Engn Res Ctr,Plus Program BK21, 291 Daehak Ro, Daejeon 34141, South Korea

[10] Korea Adv Inst Sci & Technol, Bioinformat Res Ctr, 291 Daehak Ro, Daejeon 34141, South Korea

来源：

APPLIED PHYSICS LETTERS | 2017年 / 111卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

FIELD-EFFECT TRANSISTOR; LABEL-FREE DETECTION; DEVICES;

D O I：

10.1063/1.5003106

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The sensing mechanism of nanowire field effect transistor (NWFET) biosensors is investigated by taking into consideration both the charge and dielectric effects of biomolecules. The dielectric effect of the biomolecules is dominantly reflected in the linear regime, whereas the charge property is manifested in the subthreshold regime. The findings are supported by bio-experiments and numerical simulations. This study provides a rudimentary means of understanding interactions between biomolecules and NWFET biosensors.

引用

页数：5

共 30 条

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