Direct catalytic asymmetric three-component Kabachnik-Fields reaction

被引：152

作者：

Cheng, Xu ^{[1
]}

Goddard, Richard ^{[1
]}

Buth, Gernot ^{[2
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

[2] Forschungszentrum Karlsruhe, ISS, D-76021 Karlsruhe, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 27期

关键词：

asymmetric catalysis; chiral phosphoric acid; dynamic kinetic resolution; hydrophosphonylation; organocatalysis;

D O I：

10.1002/anie.200801173

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) As mimics of α-amino acids, α-amino phosphonates have great promise as antibacterial and anti-HIV agents as well as protease inhibitors. Racemic α-branched aldehydes react, in the presence the new chiral phosphoric acid catalyst 1, directly with p-anisidine (PMPNH2) and a phosphite to furnish β-branched α-amino phosphonates highly diastereoselectively and enantioselectively. Anth = anthracenyl. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5079 / 5081

页数：3

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