A tunable, chemoselective, and moldable biodegradable polyester for cell scaffolds

被引：11

作者：

Barrett, Devin G. ^{[1
,2
]}

Yousaf, Muhammad N. ^{[1
,2
]}

机构：

[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA

来源：

CHEMBIOCHEM | 2008年 / 9卷 / 01期

关键词：

biodegradable materials; chemoselectivity; micropatterning; polyesters; tissue engineering;

D O I：

10.1002/cbic.200700550

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

(Chemical Equation Presented) Novel biodegradable polymers enable chemoselective ligand immobilization. α-Ketoglutaric acid and tetra(ethylene glycol) were polymerized to generate a poly(ester ether) with a ketone in the repeat unit. Treatment of this polymer with oxyamine-containing ligands allowed the selective introduction of functionality. By capping each chain with cross-linking groups, the polyester can be molded by UV irradiation. After curing, films can be functionalized to tune degradation rates and to act as a noncytotoxic, biospecific ligand-mediated cell adhesive scaffolds. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：62 / 66

页数：5

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