A fluorescent light-up nanoparticle probe with aggregation-induced emission characteristics and tumor-acidity responsiveness for targeted imaging and selective suppression of cancer cells

被引：68

作者：

Ding, Dan ^{[1
,2
]}

Kwok, Ryan T. K. ^{[3
,4
]}

Yuan, Youyong ^{[1
]}

Feng, Guangxue ^{[1
]}

Tang, Ben Zhong ^{[3
,4
,5
]}

Liu, Bin ^{[1
,6
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

[2] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Key Lab Bioact Mat,Minist Educ, Tianjin 300071, Peoples R China

[3] Hong Kong Univ Sci & Technol, State Key Lab Mol Neurosci, Inst Adv Study, Dept Chem,Div Biomed Engn,Div Life Sci, Kowloon, Hong Kong, Peoples R China

[4] Hong Kong Univ Sci & Technol, Inst Mol Funct Mat, Kowloon, Hong Kong, Peoples R China

[5] S China Univ Technol, State Key Lab Luminescent Mat & Devices, Guangdong Innovat Res Team, SCUT HKUST Joint Res Lab, Guangzhou 510640, Guangdong, Peoples R China

[6] Inst Mat Res & Engn A STAR, Singapore 117602, Singapore

来源：

MATERIALS HORIZONS | 2015年 / 2卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

DRUG-DELIVERY; APOPTOSIS; CONJUGATE; BIOPROBE;

D O I：

10.1039/c4mh00164h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pH-responsive light-up nanoparticle probe with aggregation-induced emission (AIE) features was designed and synthesized. The probe carries negative charges and shows very weak fluorescence under physiological conditions. In a tumor acidic extracellular micro-environment, the nanoparticle probe can switch to positive surface charge and thus significantly light up cancer cells, allowing for targeted imaging and selective suppression of cancer cells. As AIE nanoparticles are known for high fluorescence in the aggregate state, this study represents the first example of light-up AIE nanoparticle probe design.

引用

页码：100 / 105

页数：6

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