We present the first collection of tools aimed at automated genome assembly validation. This paper formalizes several mechanisms for detecting mis-assemblies, and describes their implementation in our automated validation pipeline, amosvalidate. We demonstrate the application of our pipeline in both bacterial and eukaryotic genome assemblies, and highlight several assembly errors in both draft and finished genomes. The software described is compatible with common assembly formats and is released, open-source, at http://amos.sourceforge.net.
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Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland
Semple, CAM
;
Morris, SW
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Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland
Morris, SW
;
Porteous, DJ
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Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland
Porteous, DJ
;
Evans, KL
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Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland
Semple, CAM
;
Morris, SW
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland
Morris, SW
;
Porteous, DJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland
Porteous, DJ
;
Evans, KL
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, ScotlandUniv Edinburgh, Western Gen Hosp, Mol Med Ctr,Med Genet Sect, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland