In Vivo Anomalous Diffusion and Weak Ergodicity Breaking of Lipid Granules

被引：558

作者：

Jeon, Jae-Hyung ^{[1
]}

Tejedor, Vincent ^{[2
]}

Burov, Stas ^{[3
]}

Barkai, Eli ^{[3
]}

Selhuber-Unkel, Christine ^{[4
,5
]}

Berg-Sorensen, Kirstine ^{[6
]}

Oddershede, Lene ^{[4
]}

Metzler, Ralf ^{[1
,7
]}

机构：

[1] Tech Univ Munich, Phys Dept T30g, D-85747 Garching, Germany

[2] Univ Paris 06, F-75252 Paris, France

[3] Bar Ilan Univ, Dept Phys, IL-52900 Ramat Gan, Israel

[4] Niels Bohr Inst, DK-2100 Copenhagen O, Denmark

[5] Univ Kiel, Inst Mat Sci, D-24143 Kiel, Germany

[6] Tech Univ Denmark, Dept Phys, DK-2800 Kongens Lyngby, Denmark

[7] Tampere Univ Technol, Dept Phys, FI-33101 Tampere, Finland

来源：

PHYSICAL REVIEW LETTERS | 2011年 / 106卷 / 04期

基金：

芬兰科学院;

关键词：

SUBDIFFUSION; CELL;

D O I：

10.1103/PhysRevLett.106.048103

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Combining extensive single particle tracking microscopy data of endogenous lipid granules in living fission yeast cells with analytical results we show evidence for anomalous diffusion and weak ergodicity breaking. Namely we demonstrate that at short times the granules perform subdiffusion according to the laws of continuous time random walk theory. The associated violation of ergodicity leads to a characteristic turnover between two scaling regimes of the time averaged mean squared displacement. At longer times the granule motion is consistent with fractional Brownian motion.

引用

页数：4

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