Catalytic asymmetric intramolecular hydroamination of aminoalkenes

被引：89

作者：

Ogata, Tokutaro ^{[1
]}

Ujihara, Atsushi ^{[1
]}

Tsuchida, Susumu ^{[1
]}

Shimizu, Tomoko ^{[1
]}

Kaneshige, Atsunori ^{[1
]}

Tomioka, Kiyoshi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 38期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.tetlet.2007.07.117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric intramolecular cyclization of aminoalkenes was catalyzed by a catalytic amount of n-butyllithium, diisopropylamine, and a newly designed chiral bisoxazoline in toluene to produce kinetically controlled exo-cyclized amines with up to 91% ee quantitatively. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6648 / 6650

页数：3

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