Anti-Gal-C antibodies in GBS subsequent to mycoplasma infection: Evidence of molecular mimicry

被引：88

作者：

Kusunoki, S ^{[1
]}

Shiina, M ^{[1
]}

Kanazawa, I ^{[1
]}

机构：

[1] Univ Tokyo, Dept Neurol, Grad Sch Med, Bunkyo Ku, Tokyo 1138655, Japan

来源：

NEUROLOGY | 2001年 / 57卷 / 04期

关键词：

D O I：

10.1212/WNL.57.4.736

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors previously reported the presence of antibody against galactocerebroside (Gal-C) in sera from patients with Guillain-Barre syndrome subsequent to Mycoplasma pneumoniae infection. Anti-Gal-C antibody activities in these sera were inhibited specifically by the M. pneumoniae reagent. A rabbit anti-Gal-C antibody recognized several glycolipids in M. pneumoniae. These data show that a Gal-C-like structure is present in M. pneumoniae, indicative of molecular mimicry between a major myelin glycolipid, Gal-C, and M. pneumoniae.

引用

页码：736 / 738

页数：3

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