Suppression of T3- and fatty acid-induced membrane permeability transition by L-carnitine

被引：28

作者：

Kashiwagi, A

Kanno, T

Arita, K

Ishisaka, R

Utsumi, T

Utsumi, K ^{[1
]}

机构：

[1] Kurashiki Med Ctr, Inst Med Sci, Kurashiki, Okayama 7108522, Japan

[2] Hiroshima Univ, Grad Sch Sci, Lab Amphibian Biol, Higashihiroshima 7398526, Japan

[3] Yamaguchi Univ, Fac Agr, Dept Biol Chem, Yamaguchi 7538515, Japan

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 2001年 / 130卷 / 03期

关键词：

apoptosis mechanism; cytochrome c; L-carnitine; long chain fatty acid; membrane permeability transition; mitochondria; triiodothyronine;

D O I：

10.1016/S1096-4959(01)00458-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytochrome c (Cyt. c) is known to be released from the mitochondria into the cytosol by means of the membrane permeability transition (MPT) mechanism, thereby activating caspase cascade activity, and inducing cell apoptosis. Recently we reported that L-carnitine suppressed palmitoyl-CoA-induced MPT as well as apoptosis in some cell types (Biochem. Pharmacol, in press). In the present study T-3 was found to induce MPT and Cyt. c release, while cyclosporin A (CsA), bovine serum albumin (BSA) and L-carnitine were found to inhibit this action in a concentration-dependent manner. Similarly, long chain fatty acid (LCFA) also induced MPT and Cyt. c release, which was then inhibited by CsA, BSA and L-carnitine. From these results the authors postulate that T-3-induced MPT is in part regulated by fatty acid metabolism through a dynamic balance between LCFAs and L-carnitine. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：411 / 418

页数：8

共 51 条

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