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Molecular origins of cancer: Epigenetics in cancer

被引：2399
作者：
Esteller, Manel [1 ]
机构：
[1] Spanish Natl Canc Res Ctr, Canc Epigenet Lab, Madrid 28029, Spain
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2008年 / 358卷 / 11期
关键词：
D O I：
10.1056/NEJMra072067
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Gene transcription can be activated or inhibited by a reversible modification of the gene; this modification is termed an epigenetic change. This account of epigenetics in cancer reviews the mechanisms and consequences of epigenetic changes in cancer cells and concludes with the implications of these changes for the diagnosis, prognosis, and treatment of cancer. Copyright © 2008 Massachusetts Medical Society. All rights reserved.
引用
收藏
页码：1148 / 1159
页数：12
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