Non-covalent phosphorylcholine coating reduces protein adsorption and phagocytic uptake of microparticles

被引：7

作者：

Garapaty, Anusha ^{[1
]}

Champion, Julie A. ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biomol Engn, Atlanta, GA 30332 USA

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 72期

关键词：

SELF-ASSEMBLED MONOLAYERS; POLYMER NANOPARTICLES; OXIDE NANOPARTICLES; STRONG RESISTANCE; SURFACE-CHARGE; SERUM-PROTEINS; CELLS; PEG; ACTIVATION; ADHESION;

D O I：

10.1039/c5cc03459k

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Phosphorylcholine co-polymer was assembled on model polystyrene microparticles through a simple, widely-applicable ethanol coating process. The coating rendered particles resistant to protein adsorption and phagocytosis by macrophages, making it useful for a range of biological applications.

引用

页码：13814 / 13817

页数：4

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