Proline-catalyzed asymmetric direct aldol reaction assisted by D-camphorsulfonic acid in aqueous media

被引：67

作者：

Wu, YS

Chen, Y

Deng, DS

Cai, JW ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Peoples R China

[2] Hebei Normal Univ, Chem Coll, Shijiazhuang 050016, Peoples R China

来源：

SYNLETT | 2005年 / 10期

关键词：

asymmetric direct aldol reaction; co-catalyst; proline; camphorsulfonic acid; aqueous media;

D O I：

10.1055/s-2005-869864

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric aldol reactions of aromatic aldehydes with various ketones catalyzed by L-proline with D-camphorsulfonic acid as co-catalyst have been developed in aqueous media. High reactivity and modest to excellent enantioselectivity has been achieved.

引用

收藏

页码：1627 / 1629

页数：3

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