Asymmetric hydrogenation of N-substituted maleimides by cultured plant cells

被引：15

作者：

Hirata, T

Takarada, A

Matsushima, A

Kondo, Y

Hamada, H

机构：

[1] Hiroshima Univ, Grad Sch Sci, Dept Math & Life Sci, Higashihiroshima 7398526, Japan

[2] Hiroshima Univ, Nat Sci Ctr Basic Res & Dev, Higashihiroshima 7398526, Japan

[3] Okayama Univ Sci, Dept Appl Sci, Okayama 7000005, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2004年 / 15卷 / 01期

关键词：

D O I：

10.1016/j.tetasy.2003.10.033

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The cultured suspension cells of higher plants hydrogenated the C-C double bond of N-substituted maleimides to afford the corresponding succinimides. Hydrogenation of N-phenyl-2-methylmaleimide by the cultured cells of Nicotiana tabacum proved to be highly enantioselective and gave (R)-N-phenyl-2-methylsuccinimide (99% ee). (C) 2003 Elsevier Ltd. All rights reserved.

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页码：15 / 16

页数：2

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