Palladium-Catalyzed Direct Ethynylation of C(sp3)-H Bonds in Aliphatic Carboxylic Acid Derivatives

被引：332

作者：

Ano, Yusuke ^{[1
]}

Tobisu, Mamoru ^{[1
,2
]}

Chatani, Naoto ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Engn, Ctr Atom & Mol Technol, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 33期

关键词：

C-H BONDS; GACL3-CATALYZED ORTHO-ETHYNYLATION; CARBON-HYDROGEN BONDS; DIRECT ALKYNYLATION; TERMINAL ALKYNES; COUPLING REACTIONS; ACTIVATION; COPPER; ARYLATION; FUNCTIONALIZATION;

D O I：

10.1021/ja206002m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first catalytic alkynylation of unactivated C(sp(3))-H bonds has been accomplished. The method allows for the straightforward introduction of an ethynyl group into aliphatic acid derivatives under palladium catalysis. This new reaction can be applied to the rapid elaboration of complex aliphatic acids, for example, via azide/alkyne cycloaddition.

引用

页码：12984 / 12986

页数：3

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