Asymmetric synthesis of the pyran antibiotic (-)-centrolobine

被引：54

作者：

Chandrasekhar, S ^{[1
]}

Prakash, SJ ^{[1
]}

Shyamsunder, T ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 39期

关键词：

Keck allylation; intramolecular oxy-Michael reaction; (-)-centrolobine; 2,6-disubstituted tetrahydropyran;

D O I：

10.1016/j.tetlet.2005.07.162

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An expedient total synthesis of (-)-centrolobine is achieved involving asymmetric Keck allylation and stereoselective intramolecular oxy-Michael reactions as key steps in 8% overall yield. (c) 2005 Published by Elsevier Ltd.

引用

页码：6651 / 6653

页数：3

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