A novel method for the preparation of α,α′-difluoroesters and acids using BrF3

被引：17

作者：

Hagooly, A ^{[1
]}

Sasson, R ^{[1
]}

Rozen, S ^{[1
]}

机构：

[1] Tel Aviv Univ, Sch Chem, Raymond & Beverly Sackler Fac Exact Sci, IL-69978 Tel Aviv, Israel

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 21期

关键词：

D O I：

10.1021/jo034829i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl-, haloalkyl-, and ketoalkyl-2-ethoxycarbonyl-1,3-dithianes were easily made from the appropriate primary or secondary alkyl bromides, 1,3-dithiane, and ethyl chloroformate. They were reacted with BrF3 to form the corresponding alpha,alpha-difluoro esters in 65-75% yield. Reaction conditions are very mild (1-2 min, 0 degreesC). The two sulfur atoms of the dithiane are essential for the reaction.

引用

页码：8287 / 8289

页数：3

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