Microwave-assisted Mannich-type three-component reactions

被引：63

作者：

Leadbeater, Nicholas E. ^{[1
]}

Torenius, Hanna M. ^{[1
]}

Tye, Heather ^{[2
]}

机构：

[1] Kings Coll London, Dept Chem, Strand, London WC2R 2LS, England

[2] Evotec OAI, Abingdon OX14 4SD, Oxon, England

来源：

MOLECULAR DIVERSITY | 2003年 / 7卷 / 2-4期

关键词：

ionic liquids; mannich reaction; microwave chemistry; multi-component reactions;

D O I：

10.1023/B:MODI.0000006822.51884.e6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mannich-type three-component reactions have been performed successfully using microwave heating in conjunction with the use of ionic liquids as heating agents. Good product yields and short reaction times have been achieved.

引用

页码：135 / 144

页数：10

共 32 条

[1] Microwave activation in phase transfer catalysis [J].

Deshayes, S ;

Liagre, M ;

Loupy, A ;

Luche, JL ;

Petit, A .

TETRAHEDRON, 1999, 55 (36) :10851-10870

[2] The solid phase synthesis of complex propargylamines using the combination of Sonogashira and Mannich reactions [J].

Dyatkin, AB ;

Rivero, RA .

TETRAHEDRON LETTERS, 1998, 39 (22) :3647-3650

[3] Dielectric parameters relevant to microwave dielectric heating [J].

Gabriel, C ;

Gabriel, S ;

Grant, EH ;

Halstead, BSJ ;

Mingos, DMP .

CHEMICAL SOCIETY REVIEWS, 1998, 27 (03) :213-223

[4]

Hayes B.L., 2002, MICROWAVE SYNTHESIS

[5] High-speed combinatorial synthesis utilizing microwave irradiation [J].

Kappe, CO .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (03) :314-320

[6] Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog [J].

Kappe, CO .

ACCOUNTS OF CHEMICAL RESEARCH, 2000, 33 (12) :879-888

[7] Highly diastereoselective synthesis of 1,3-oxazolidines under thermodynamic control using focused microwave irradiation under solvent-free conditions [J].

Kuhnert, N ;

Danks, TN .

GREEN CHEMISTRY, 2001, 3 (02) :68-70

[8] Microwave-accelerated homogeneous catalysis in organic chemistry [J].

Larhed, M ;

Moberg, C ;

Hallberg, A .

ACCOUNTS OF CHEMICAL RESEARCH, 2002, 35 (09) :717-727

[9] Ionic liquids as reagents and solvents in conjunction with microwave heating: rapid synthesis of alkyl halides from alcohols and nitriles from aryl halides [J].

Leadbeater, NE ;

Torenius, HM ;

Tye, H .

TETRAHEDRON, 2003, 59 (13) :2253-2258

[10] A study of the ionic liquid mediated microwave heating of organic solvents [J].

Leadbeater, NE ;

Torenius, HM .

JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (09) :3145-3148

← 1 2 3 4 →