Functionalization of Peptides and Proteins by Mukaiyama Aldol Reaction

被引：53

作者：

Alam, Jenefer ^{[1
,2
]}

Keller, Thomas H. ^{[2
]}

Loh, Teck-Peng ^{[1
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore

[2] Novartis Inst Trop Dis, Singapore 138670, Singapore

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 28期

关键词：

BIOCONJUGATION; METATHESIS;

D O I：

10.1021/ja102733a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The scope of the catalyst-free water-based Mukaiyama aldol reaction was explored through its application to the site-selective functionalization of N-terminal aldehydes of peptides and proteins. Various functional groups were introduced under mild and environmentally friendly conditions, with the first demonstration of aldol C-C bond formation in protein labeling studies. The efficiency and speed achieved in protein labeling can be of special interest in chemical biology studies.

引用

页码：9546 / 9548

页数：3

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