Enabling plant synthetic biology through genome engineering

被引：159

作者：

Baltes, Nicholas J.

Voytas, Daniel F. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2015年 / 33卷 / 02期

关键词：

synthetic biology; sequence-specific nuclease; zinc-finger nuclease; TALEN; CRISPR/Cas; genome engineering; STRAND BREAK REPAIR; ZINC-FINGER NUCLEASES; TARGETED MUTAGENESIS; HOMOLOGOUS RECOMBINATION; TRANSCRIPTION FACTORS; GENE-EXPRESSION; TRAIT STACKING; HUMAN-CELLS; I-CREI; T-DNA;

D O I：

10.1016/j.tibtech.2014.11.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Synthetic biology seeks to create new biological systems, including user-designed plants and plant cells. These systems can be employed for a variety of purposes, ranging from producing compounds of industrial or therapeutic value, to reducing crop losses by altering cellular responses to pathogens or climate change. To realize the full potential of plant synthetic biology, techniques are required that provide control over the genetic code - enabling targeted modifications to DNA sequences within living plant cells. Such control is now within reach owing to recent advances in the use of sequence-specific nucleases to precisely engineer genomes. We discuss here the enormous potential provided by genome engineering for plant synthetic biology.

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页码：120 / 131

页数：12

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