Hydrogels in drug delivery: Progress and challenges

被引：2905

作者：

Hoare, Todd R. ^{[2
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med,Lab Biomat & Drug Delivery, Dept Anesthesiol,Div Crit Care Med, Boston, MA 02115 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

POLYMER | 2008年 / 49卷 / 08期

关键词：

hydrogels; drug delivery; polymer science;

D O I：

10.1016/j.polymer.2008.01.027

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

There has been considerable progress in recent years in addressing the clinical and pharmacological limitations of hydrogels for drug delivery applications but substantial challenges remain. Here we discuss recent progress in overcoming these challenges, particularly with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs from hydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1993 / 2007

页数：15

共 139 条

[91] Liposomal drugs dispersed in hydrogels - Effect of liposome, drug and gel properties on drug release kinetics [J].

Mourtas, Spyridon ;

Fotopoulou, Styliani ;

Duraj, Stela ;

Sfika, Vassiliki ;

Tsakiroglou, Christos ;

Antimisiaris, Sophia G. .

COLLOIDS AND SURFACES B-BIOINTERFACES, 2007, 55 (02) :212-221

[92] Drug diffusion in hydrophobically modified N,N-dimethylacrylamide hydrogels [J].

Mullarney, Matthew P. ;

Seery, Thomas A. P. ;

Weiss, R. A. .

POLYMER, 2006, 47 (11) :3845-3855

[93] Synthesis and characterization of stimuli-sensitive hydrogels having a different length of ethylene glycol chains carrying phosphate groups: loading and release of lysozyme [J].

Nakamae, K ;

Nishino, T ;

Kato, K ;

Miyata, T ;

Hoffman, AS .

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2004, 15 (11) :1435-1446

[94] Self-gelling primaquine-gum arabic conjugate: An injectable controlled delivery system for primaquine [J].

Nishi, K. K. ;

Jayakrishnan, A. .

BIOMACROMOLECULES, 2007, 8 (01) :84-90

[95] Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles [J].

Nowak, AP ;

Breedveld, V ;

Pakstis, L ;

Ozbas, B ;

Pine, DJ ;

Pochan, D ;

Deming, TJ .

NATURE, 2002, 417 (6887) :424-428

[96] Dexamethasone-functionalized gels induce osteogenic differentiation of encapsulated hMSCs [J].

Nuttelman, CR ;

Tripodi, MC ;

Anseth, KS .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 76A (01) :183-195

[97] Formation of the first injectable poly(vinyl alcohol) hydrogel by mixing of functional PVA precursors [J].

Ossipov, Dmitri A. ;

Brannvall, Karin ;

Forsberg-Nilsson, Karin ;

Hilborn, Jons .

JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 106 (01) :60-70

[98] Controlled release of lidocaine from injectable gels and efficacy in rat sciatic nerve block [J].

Paavola, A ;

Yliruusi, J ;

Kajimoto, Y ;

Kalso, E ;

Wahlstrom, T ;

Rosenberg, P .

PHARMACEUTICAL RESEARCH, 1995, 12 (12) :1997-2002

[99] Delivery of TGF-β1 and chondrocytes via injectable, biodegradable hydrogels for cartilage tissue engineering applications [J].

Park, H ;

Temenoff, JS ;

Holland, TA ;

Tabata, Y ;

Mikos, AG .

BIOMATERIALS, 2005, 26 (34) :7095-7103

[100]

Park YS, 2004, POLYM-KOREA, V28, P59

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