Hydrogels in drug delivery: Progress and challenges

被引：2905

作者：

Hoare, Todd R. ^{[2
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med,Lab Biomat & Drug Delivery, Dept Anesthesiol,Div Crit Care Med, Boston, MA 02115 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

POLYMER | 2008年 / 49卷 / 08期

关键词：

hydrogels; drug delivery; polymer science;

D O I：

10.1016/j.polymer.2008.01.027

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

There has been considerable progress in recent years in addressing the clinical and pharmacological limitations of hydrogels for drug delivery applications but substantial challenges remain. Here we discuss recent progress in overcoming these challenges, particularly with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs from hydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1993 / 2007

页数：15

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