Hydrogels in drug delivery: Progress and challenges

被引：2905

作者：

Hoare, Todd R. ^{[2
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med,Lab Biomat & Drug Delivery, Dept Anesthesiol,Div Crit Care Med, Boston, MA 02115 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

POLYMER | 2008年 / 49卷 / 08期

关键词：

hydrogels; drug delivery; polymer science;

D O I：

10.1016/j.polymer.2008.01.027

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

There has been considerable progress in recent years in addressing the clinical and pharmacological limitations of hydrogels for drug delivery applications but substantial challenges remain. Here we discuss recent progress in overcoming these challenges, particularly with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs from hydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1993 / 2007

页数：15

共 139 条

[21] Release of ciprofloxacin from poloxamer-graft-hyaluronic acid hydrogels in vitro [J].

Cho, KY ;

Chung, TW ;

Kim, BC ;

Kim, MK ;

Lee, JH ;

Wee, WR ;

Cho, CS .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 260 (01) :83-91

[22]

Choi HS, 2002, MACROMOL BIOSCI, V2, P298, DOI 10.1002/1616-5195(200208)2:6<298::AID-MABI298>3.0.CO

[23]

2-#

[24] Self-rupturing microcapsules [J].

De Geest, BG ;

Déjugnat, C ;

Sukhorukov, GB ;

Braeckmans, K ;

De Smedt, SC ;

Demeester, J .

ADVANCED MATERIALS, 2005, 17 (19) :2357-+

[25] Physically crosslinked dextran hydrogels by stereocomplex formation of lactic acid oligomers: degradation and protein release behavior [J].

de Jong, SJ ;

van Eerdenbrugh, B ;

van Nostrum, CF ;

Kettenes-van de Bosch, JJ ;

Hennink, WE .

JOURNAL OF CONTROLLED RELEASE, 2001, 71 (03) :261-275

[26] Design and application of self-assembled low molecular weight hydrogels [J].

de Loos, M ;

Feringa, BL ;

van Esch, JH .

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (17) :3615-3631

[27] Synthesis and characterization of RGD peptide grafted poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-glutamic acid) triblock copolymer [J].

Deng, C ;

Tian, HY ;

Zhang, PB ;

Sun, J ;

Chen, XS ;

Jing, XB .

BIOMACROMOLECULES, 2006, 7 (02) :590-596

[28] Drug release from pH-responsive thermogelling pentablock copolymers [J].

Determan, Michael D. ;

Cox, James P. ;

Mallapragada, Surya K. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2007, 81A (02) :326-333

[29] PROLONGATION OF LIDOCAINE-INDUCED EPIDURAL-ANESTHESIA BY MEDIUM MOLECULAR-WEIGHT HYALURONIC-ACID FORMULATIONS - PHARMACODYNAMIC AND PHARMACOKINETIC STUDIES IN THE RABBIT [J].

DOHERTY, MM ;

HUGHES, PJ ;

KORSZNIAK, NV ;

CHARMAN, WN .

ANESTHESIA AND ANALGESIA, 1995, 80 (04) :740-746

[30] Controlled release of tethered molecules via engineered hydrogel degradation: Model development and validation [J].

DuBose, JW ;

Cutshall, C ;

Metters, AT .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2005, 74A (01) :104-116

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