Hydrogels in drug delivery: Progress and challenges

被引：2905

作者：

Hoare, Todd R. ^{[2
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med,Lab Biomat & Drug Delivery, Dept Anesthesiol,Div Crit Care Med, Boston, MA 02115 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

POLYMER | 2008年 / 49卷 / 08期

关键词：

hydrogels; drug delivery; polymer science;

D O I：

10.1016/j.polymer.2008.01.027

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

There has been considerable progress in recent years in addressing the clinical and pharmacological limitations of hydrogels for drug delivery applications but substantial challenges remain. Here we discuss recent progress in overcoming these challenges, particularly with regards to effectively delivering hydrogels inside the body without implantation, prolonging the release kinetics of drugs from hydrogels, and expanding the nature of drugs which can be delivered using hydrogel-based approaches. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：1993 / 2007

页数：15

共 139 条

[11]

Bouhadir KH, 2000, J PHARM SCI-US, V89, P910, DOI 10.1002/1520-6017(200007)89:7<910::AID-JPS8>3.0.CO

[12]

2-#

[13]

Bulpitt P, 1999, J BIOMED MATER RES, V47, P152

[14] Mechanism and kinetics of the crosslinking reaction between biopolymers containing primary amine groups and genipin [J].

Butler, MF ;

Ng, YF ;

Pudney, PDA .

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2003, 41 (24) :3941-3953

[15] Injectable glycosaminoglycan hydrogels for controlled release of human basic fibroblast growth factor [J].

Cai, SS ;

Liu, YC ;

Shu, XZ ;

Prestwich, GD .

BIOMATERIALS, 2005, 26 (30) :6054-6067

[16] Synthesis and study of and controlled release from nanoparticles and their networks based on functionalized hydroxypropylcellulose [J].

Cai, T ;

Hu, ZB ;

Ponder, B ;

St John, J ;

Moro, D .

MACROMOLECULES, 2003, 36 (17) :6559-6564

[17] Use of a polymethylmethacrylate cervical cage in the treatment of single-level cervical disc disease [J].

Chen, JF ;

Wu, CT ;

Lee, SC ;

Lee, ST .

JOURNAL OF NEUROSURGERY-SPINE, 2005, 3 (01) :24-28

[18] Injectable microparticle-gel system for prolonged and localized lidocaine release.: II.: In vivo anesthetic effects [J].

Chen, PC ;

Kohane, DS ;

Park, YJ ;

Bartlett, RH ;

Langer, R ;

Yang, VC .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2004, 70A (03) :459-466

[19] A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery [J].

Chen, SC ;

Wu, YC ;

Mi, FL ;

Lin, YH ;

Yu, LC ;

Sung, HW .

JOURNAL OF CONTROLLED RELEASE, 2004, 96 (02) :285-300

[20] Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels [J].

Chivukula, P ;

Dusek, K ;

Wang, D ;

Dusková-Smrcková, M ;

Kopecková, P ;

Kopecek, J .

BIOMATERIALS, 2006, 27 (07) :1140-1151

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