Solution-phase synthesis of chiral O-acyl isodipeptides

被引：24

作者：

El Khatib, Mirna ^{[1
]}

Jauregui, Lilibeth ^{[1
]}

Tala, Srinivasa R. ^{[1
]}

Khelashvili, Levan ^{[1
]}

Katritzky, Alan R. ^{[1
,2
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] King Abdulaziz Univ, Dept Chem, Jeddah 21589, Saudi Arabia

来源：

MEDCHEMCOMM | 2011年 / 2卷 / 11期

关键词：

AMYLOID-BETA PEPTIDE; SEQUENCE-CONTAINING PEPTIDES; WATER-SOLUBLE PRODRUGS; ISOPEPTIDE METHOD; MIGRATION REACTION; CLICK PEPTIDE; A-BETA-1-42; ISOPEPTIDE; EFFICIENT SYNTHESIS; UNIT; TRANSITION;

D O I：

10.1039/c1md00130b

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

O-Acylation of N-Boc-protected-serine and -threonine with N-Pg-(alpha-aminoacyl)benzotriazoles afforded the chiral O-acylated isodipeptides at 23 degrees C in yields of 74-91%.

引用

页码：1087 / 1092

页数：6

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