Highly constrained dipeptoid analogues containing a type II′ β-turn mimic as novel and selective CCK-A receptor ligands

被引：16

作者：

de la Figuera, N

Martín-Martínez, M

Herranz, R

García-López, MT

Latorre, M

Cenarruzabeitia, E

del Río, J

González-Muñiz, R

机构：

[1] CSIC, Inst Quim Med, E-28006 Madrid, Spain

[2] Univ Navarra, Dept Farmacol, Pamplona 31008, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期

关键词：

cholecystokinin; peptoids; antagonists;

D O I：

10.1016/S0960-894X(98)00677-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conformationally constrained dipeptoid analogues containing the type II' beta-turn mimic (2S,5S,11bR)-2-amino-3-oxohexahydroindolizino[8,7-b] indoled-carboxylate framework in place of the alpha-MeTrp residue, show high binding affinity and selectivity for CCK-A receptors, suggesting that a turn-like conformation could contribute to the bioactive conformation at this CCK receptor subtype. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：43 / 48

页数：6

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