Direct, iridium-catalyzed enantioselective and regioselective allylic etherification with aliphatic alcohols

被引：103

作者：

Ueno, Satoshi ^{[1
]}

Hartwig, John F. ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 10期

关键词：

alkoxides; allylic substitution; asymmetric synthesis iridium; metallacycle;

D O I：

10.1002/anie.200705267

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) From alcohol to ether: Iridium-catalyzed allylations yield α chiral ether derivatives directly from aliphatic alcohols with a simple alkali metal base (see equation). These reactions form ethers from primary, secondary, and tertiary alkoxides with high enantioselectivity. By-products from isomerization were suppressed by the use of an alkyne additive. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：1928 / 1931

页数：4

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