Concise survey of Staphylococcus aureus virulence factors that promote adhesion and damage to peri-implant tissues

被引：40

作者：

Arciola, Carla Renata ^{[1
,2
]}

Visai, Livia ^{[3
,4
,5
]}

Testoni, Francesca ^{[1
]}

Arciola, Susanna ^{[1
,6
]}

Campoccia, Davide ^{[1
]}

Speziale, Pietro ^{[3
]}

Montanaro, Lucio ^{[1
,2
]}

机构：

[1] Rizzoli Orthopaed Inst, Res Unit Implant Infect, I-40136 Bologna, Italy

[2] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

[3] Univ Pavia, Dept Biochem, I-27100 Pavia, Italy

[4] Univ Pavia, Ctr Tissue Engn CIT, Salvatore Maugeri Fdn IRCCS, I-27100 Pavia, Italy

[5] Int Ctr Studies & Res Biomed ICB, Luxembourg, Luxembourg

[6] Osped Buon Consiglio Fatebenefratelli, Naples, Italy

来源：

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS | 2011年 / 34卷 / 09期

关键词：

Staphylococcus aureus; MSCRAMMs; Biofilm; Toxins; agr; Implant infection; FIBRONECTIN-BINDING PROTEINS; MOLECULAR EPIDEMIOLOGY; COLLAGEN ADHESIN; INTERCELLULAR-ADHESION; ICA LOCUS; ORTHOPEDIC INFECTIONS; CELLULAR INVASION; BIOFILM FORMATION; SEPTIC ARTHRITIS; SLIME PRODUCTION;

D O I：

10.5301/ijao.5000046

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Staphylococcus aureus is the leading cause of infection in orthopedic implants and of osteomyelitis consequent to it. Here we focus on the wide array of virulence factors that endow S. aureus with its abilities to colonize pen-prosthesis tissues and to attack and damage them. Following an infective strategy orchestrated by agr locus, Staphylococcus aureus first deploys virulence factors for adhesion to the prosthesis and pen-prosthesis tissues and then launches its attack by delivering destructive factors.

引用

收藏

页码：771 / 780

页数：10

相关论文

共 99 条

[1] Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases [J].

Agerer, F ;

Michel, A ;

Ohlsen, K ;

Hauck, CR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (43) :42524-42531

[2] Factors influencing the internalization of Staphylococcus aureus and impacts on the course of infections in humans [J].

Alexander, EH ;

Hudson, MC .

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2001, 56 (3-4) :361-366

[3] A characterization of DNA release in Pseudomonas aeruginosa cultures and biofilms [J].

Allesen-Holm, M ;

Barken, KB ;

Yang, L ;

Klausen, M ;

Webb, JS ;

Kjelleberg, S ;

Molin, S ;

Givskov, M ;

Tolker-Nielsen, T .

MOLECULAR MICROBIOLOGY, 2006, 59 (04) :1114-1128

[4] New concepts and new weapons in implant infections [J].

Arciola, Carla Renata .

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2009, 32 (09) :533-536

[5] Detection of biofilm formation in Staphylococcus epidermidis from implant infections.: Comparison of a PCR-method that recognizes the presence of ica genes with two classic phenotypic methods [J].

Arciola, CR ;

Campoccia, D ;

Baldassarri, L ;

Donati, ME ;

Pirini, V ;

Gamberini, S ;

Montanaro, L .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2006, 76A (02) :425-430

[6] Etiology of implant orthopedic infections: A survey on 1027 clinical isolates [J].

Arciola, CR ;

An, YH ;

Campoccia, D ;

Donati, ME ;

Montanaro, L .

INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, 2005, 28 (11) :1091-1100

[7] Search for the insertion element IS256 within the ica locus of Staphylococcus epidermidis clinical isolates collected from biomaterial-associated infections [J].

Arciola, CR ;

Campoccia, D ;

Gamberini, S ;

Rizzi, S ;

Donati, ME ;

Baldassarri, L ;

Montanaro, L .

BIOMATERIALS, 2004, 25 (18) :4117-4125

[8] In catheter infections by Staphylococcus epidermidis the intercellular adhesion (ica) locus is a molecular marker of the virulent slime-producing strains [J].

Arciola, CR ;

Baldassarri, L ;

Montanaro, L .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 59 (03) :557-562

[9] Presence of icaA and icaD genes and slime production in a collection of staphylococcal strains from catheter-associated infections [J].

Arciola, CR ;

Baldassarri, L ;

Montanaro, L .

JOURNAL OF CLINICAL MICROBIOLOGY, 2001, 39 (06) :2151-2156

[10] Hydroxyapatite-coated orthopaedic screws as infection resistant materials: in vitro study [J].

Arciola, CR ;

Montanaro, L ;

Moroni, A ;

Giordano, M ;

Pizzoferrato, A ;

Donati, ME .

BIOMATERIALS, 1999, 20 (04) :323-327

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