The structure of protein evolution and the evolution of protein structure

被引：69

作者：

Goldstein, Richard A. ^{[1
]}

机构：

[1] Natl Inst Med Res, Div Math Biol, London NW7 1AA, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2008年 / 18卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.sbi.2008.01.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The observed distribution of protein structures can give us important clues about the underlying evolutionary process, imposing important constraints on possible models. The availability of results from an increasing number of genome projects has made the development of these models an active area of research. Models explaining the observed distribution of structures have focused on the inherent functional capabilities and structural properties of different folds and on the evolutionary dynamics. Increasingly, these elements are being combined.

引用

页码：170 / 177

页数：8

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