A Unique Approach to Catalyst-Free, One-Pot Synthesis of Spirooxindole-Pyrazolines

被引：22

作者：

Alizadeh, Abdolali ^{[1
]}

Zohreh, Nasrin ^{[1
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

SYNLETT | 2012年 / 03期

关键词：

spirooxindole; isatin; spiropyrazole; pyrazoline; 1,1-bis(methylthio)-2-nitroethylene; one-pot reaction; EFFICIENT SYNTHESIS; NATURAL-PRODUCTS; CONSTRUCTION; DISCOVERY;

D O I：

10.1055/s-0031-1290322

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A pseudo-five-component synthesis of spirooxindole-pyrazolines via a one-pot and catalyst-free reaction under mild conditions is reported. The 1,1-bishydrazino-2-nitroethylene intermediate generated in situ from the addition of aqueous hydrazine to 1,1-bis(methylthio)-2-nitroethylene is trapped by two equivalents of isatin derivatives to obtain the title compounds.

引用

收藏

页码：428 / 432

页数：5

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