Cyclisation of histidine containing peptides in the solid-phase by anchoring the imidazole ring to trityl resins

被引：41

作者：

Sabatino, G

Chelli, M

Mazzucco, S

Ginanneschi, M

Papini, AM

机构：

[1] Univ Florence, Dipartimento Chim Organ Ugo Schiff, I-50121 Florence, Italy

[2] Univ Florence, CNR, Ctr Studio Chim & Struttura Composti Eterocicl &, I-50121 Florence, Italy

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 04期

关键词：

solid-phase synthesis; peptides; cyclisation; piperazines;

D O I：

10.1016/S0040-4039(98)02459-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Head-to-tail histidine containing cyclopeptides can be efficiently synthesised by a three-dimensional orthogonal solid-phase strategy (Fmoc/tBu/allyl) via anchoring the imidazole ring to trityl-resins. Furthermore, Fmoc-His(Trt-(R))-OAl can be a useful starting support for the preparation of diketopiperazine combinatorial libraries. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：809 / 812

页数：4

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