When Signaling Kinases Meet Histones and Histone Modifiers in the Nucleus

被引：119

作者：

Baek, Sung Hee ^{[1
]}

机构：

[1] Seoul Natl Univ, Creat Res Initiat Ctr Chromatin Dynam, Dept Biol Sci, Seoul 151742, South Korea

来源：

MOLECULAR CELL | 2011年 / 42卷 / 03期

关键词：

NF-KAPPA-B; EZH2 SUPPRESSES METHYLATION; DNA-DAMAGE RESPONSE; H3; PHOSPHORYLATION; AURORA-B; POSTTRANSLATIONAL MODIFICATIONS; TRANSCRIPTIONAL ACTIVATION; GENE-EXPRESSION; CENP-A; CHROMATIN MODIFICATIONS;

D O I：

10.1016/j.molcel.2011.03.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signaling pathways involve cascades of protein phosphorylation and ultimately affect regulation of transcription in the nucleus. However, most of the kinases in these pathways have not been generally considered to directly modulate transcription thus far. Here, recent significant progress in the field elucidating direct modifications of histones and histone modifiers by upstream kinases is summarized, and future directions are discussed.

引用

收藏

页码：274 / 284

页数：11

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