When Signaling Kinases Meet Histones and Histone Modifiers in the Nucleus

被引：119

作者：

Baek, Sung Hee ^{[1
]}

机构：

[1] Seoul Natl Univ, Creat Res Initiat Ctr Chromatin Dynam, Dept Biol Sci, Seoul 151742, South Korea

来源：

MOLECULAR CELL | 2011年 / 42卷 / 03期

关键词：

NF-KAPPA-B; EZH2 SUPPRESSES METHYLATION; DNA-DAMAGE RESPONSE; H3; PHOSPHORYLATION; AURORA-B; POSTTRANSLATIONAL MODIFICATIONS; TRANSCRIPTIONAL ACTIVATION; GENE-EXPRESSION; CENP-A; CHROMATIN MODIFICATIONS;

D O I：

10.1016/j.molcel.2011.03.022

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Signaling pathways involve cascades of protein phosphorylation and ultimately affect regulation of transcription in the nucleus. However, most of the kinases in these pathways have not been generally considered to directly modulate transcription thus far. Here, recent significant progress in the field elucidating direct modifications of histones and histone modifiers by upstream kinases is summarized, and future directions are discussed.

引用

收藏

页码：274 / 284

页数：11

相关论文

共 101 条

[11] Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins [J].

Carmena, Mar ;

Ruchaud, Sandrine ;

Earnshaw, William C. .

CURRENT OPINION IN CELL BIOLOGY, 2009, 21 (06) :796-805

[12] Histone H3 phosphorylation Universal code or lineage specific dialects? [J].

Cerutti, Heriberto ;

Casas-Mollano, J. Armando .

EPIGENETICS, 2009, 4 (02) :71-75

[13] Akt-mediated phsophorylationof EZH2 suppresses methylation of lysine 27 in histone H3 [J].

Cha, TL ;

Zhou, BHP ;

Xia, WY ;

Wu, YD ;

Yang, CC ;

Chen, CT ;

Ping, B ;

Otte, AP ;

Hung, MC .

SCIENCE, 2005, 310 (5746) :306-310

[14] Cyclin-dependent kinases regulate epigenetic gene silencing through phosphorylation of EZH2 [J].

Chen, Shuai ;

Bohrer, Laura R. ;

Rai, Aswathy N. ;

Pan, Yunqian ;

Gan, Lu ;

Zhou, Xianzheng ;

Bagchi, Anindya ;

Simon, Jeffrey A. ;

Huang, Haojie .

NATURE CELL BIOLOGY, 2010, 12 (11) :1108-U118

[15] Signaling to chromatin through histone modifications [J].

Cheung, P ;

Allis, CD ;

Sassone-Corsi, P .

CELL, 2000, 103 (02) :263-271

[16] Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase [J].

Cheung, WL ;

Ajiro, K ;

Samejima, K ;

Kloc, M ;

Cheung, P ;

Mizzen, CA ;

Beeser, A ;

Etkin, LD ;

Chernoff, J ;

Earnshaw, WC ;

Allis, CD .

CELL, 2003, 113 (04) :507-517

[17] Covalent histone modifications - miswritten, misinterpreted and mis-erased in human cancers [J].

Chi, Ping ;

Allis, C. David ;

Wang, Gang Greg .

NATURE REVIEWS CANCER, 2010, 10 (07) :457-469

[18] Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase α [J].

Choi, HS ;

Choi, BY ;

Cho, YY ;

Zhu, F ;

Bode, AM ;

Dong, ZG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (14) :13545-13553

[19] Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions [J].

Cook, Peter J. ;

Ju, Bong Gun ;

Telese, Francesca ;

Wang, Xiangting ;

Glass, Christopher K. ;

Rosenfeld, Michael G. .

NATURE, 2009, 458 (7238) :591-U53

[20] Mitotic phosphorylation of histone H3: Spatio-temporal regulation by mammalian aurora kinases [J].

Crosio, C ;

Fimia, GM ;

Loury, R ;

Kimura, M ;

Okano, Y ;

Zhou, HY ;

Sen, S ;

Allis, CD ;

Sassone-Corsi, P .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (03) :874-885

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