Three multicomponent reactions of 3,5-dimethyl-4-nitroisoxazole

被引:20
作者
Adamo, Mauro F. A. [1 ]
Konda, Vivekananda R. [1 ]
Donati, Donato [2 ]
Sarti-Fantoni, Piero [3 ]
Torroba, Tomas [4 ]
机构
[1] Royal Coll Surgeons Ireland, Ctr Synth & Chem Biol, Dept Pharmaceut & Med Chem, Dublin, Ireland
[2] Univ Siena, Dipartimento Chim, I-53100 Siena, Italy
[3] Univ Florence, Dipartimento Chim Organ, I-50019 Florence, Italy
[4] Univ Burgos, Fac Ciencias, Burgos 09001, Spain
关键词
D O I
10.1016/j.tet.2007.07.015
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The title compound is used to prepare 3-arylglutaric acids, bis-isoxazoles and bis-pyrazoles from commercially available materials. The methodologies described have afforded important synthetic intermediates in high yields and without the use of chromatography. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码:9741 / 9745
页数:5
相关论文
共 15 条
[1]   Modular syntheses of isoxazoloazepinones and pyrazoloazepinones [J].
Adamo, Mauro F. A. ;
Duffy, Eleanor F. ;
Donati, Donato ;
Sarti-Fantoni, Piero .
TETRAHEDRON, 2007, 63 (12) :2684-2688
[2]   Multicomponent synthesis of 3-indolepropionic acids [J].
Adamo, Mauro F. A. ;
Konda, Vivekananda R. .
ORGANIC LETTERS, 2007, 9 (02) :303-305
[3]  
Adamo MFA, 2007, HETEROCYCLES, V71, P1173
[4]   Modular synthesis of isoxazolopyridones and pyrazolopyridones [J].
Adamo, Mauro F. A. ;
Duffy, Eleanor F. ;
Donati, Donato ;
Sarti-Fantoni, Piero .
TETRAHEDRON, 2007, 63 (09) :2047-2052
[5]   Multicomponent synthesis of 3-heteroarylpropionic acids [J].
Adamo, Mauro F. A. ;
Duffy, Eleanor F. .
ORGANIC LETTERS, 2006, 8 (22) :5157-5159
[6]   Multicomponent synthesis of spiroisoxazolines [J].
Adamo, MFA ;
Donati, D ;
Duffy, EF ;
Sarti-Fantoni, P .
JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (21) :8395-8399
[7]   The reactivity of 3-methyl-4-nitro-5-styrylisoxazole with some bis-enolisable ketones [J].
Adamo, MFA ;
Chimichi, S ;
De Sio, F ;
Donati, D ;
Sarti-Fantoni, P .
TETRAHEDRON LETTERS, 2002, 43 (23) :4157-4160
[8]   CHEMOENZYMATIC ENANTIOSELECTIVE SYNTHESIS OF BACLOFEN [J].
CHENEVERT, R ;
DESJARDINS, M .
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1994, 72 (11) :2312-2317
[9]   CHEMOENZYMATIC SYNTHESIS OF BOTH ENANTIOMERS OF BACLOFEN [J].
CHENEVERT, R ;
DESJARDINS, M .
TETRAHEDRON LETTERS, 1991, 32 (34) :4249-4250
[10]  
Homann MJ, 2001, ADV SYNTH CATAL, V343, P744, DOI 10.1002/1615-4169(200108)343:6/7<744::AID-ADSC744>3.0.CO