Chemical Modification of Oligonucleotides for Therapeutic, Bioanalytical and other Applications

被引：91

作者：

Bell, Neil M. ^{[1
]}

Micklefield, Jason ^{[1
]}

机构：

[1] Univ Manchester, Sch Chem, Manchester Interdisciplinary Bioctr, Manchester M1 7DN, Lancs, England

来源：

CHEMBIOCHEM | 2009年 / 10卷 / 17期

关键词：

antisense agents; conjugation; nucleic acids; oligonucleotides; RNAi; PEPTIDE NUCLEIC-ACIDS; RNA-INTERFERENCE; ANTISENSE OLIGONUCLEOTIDES; ANTIVIRAL ACTIVITY; DNA; INHIBITION; EXPRESSION; PNA; DESIGN; MICE;

D O I：

10.1002/cbic.200900341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2691 / 2703

页数：13

共 104 条

[1] New oligonucleotide analogues based on morpholine subunits joined by oxalyl diamide tether [J].

Abramova, Tatiana V. ;

Kassakin, Marat F. ;

Lomzov, Alexander A. ;

Pyshnyi, Dmitrii V. ;

Silnikov, Vladimir N. .

BIOORGANIC CHEMISTRY, 2007, 35 (03) :258-275

[2] Isostable DNA [J].

Ahlborn, Carolin ;

Siegmund, Karsten ;

Richert, Clemens .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (49) :15218-15232

[3]

Ahmadibeni Y., 2007, ANGEW CHEM, V719, P4823

[4] Synthesis and evaluation of modified oligodeoxynucleotides containing diphosphodiester internucleotide linkages [J].

Ahmadibeni, Yousef ;

Parang, Keykavous .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (25) :4739-4743

[5] Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro [J].

Alotte, Christine ;

Martin, Amaury ;

Caldarelli, Sergio A. ;

Di Giorgio, Audrey ;

Condom, Roger ;

Zoulim, Fabien ;

Durantel, David ;

Hantz, Olivier .

ANTIVIRAL RESEARCH, 2008, 80 (03) :280-287

[6] ANTIVIRAL ACTIVITY OF A PHOSPHOROTHIOATE OLIGONUCLEOTIDE COMPLEMENTARY TO RNA OF THE HUMAN CYTOMEGALOVIRUS MAJOR IMMEDIATE-EARLY REGION [J].

AZAD, RF ;

DRIVER, VB ;

TANAKA, K ;

CROOKE, RM ;

ANDERSON, KP .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (09) :1945-1954

[7] ANTIVIRAL ACTIVITY OF A PHOSPHOROTHIOATE OLIGONUCLEOTIDE COMPLEMENTARY TO HUMAN CYTOMEGALOVIRUS RNA WHEN USED IN COMBINATION WITH ANTIVIRAL NUCLEOSIDE ANALOGS [J].

AZAD, RF ;

BROWNDRIVER, V ;

BUCKHEIT, RW ;

ANDERSON, KP .

ANTIVIRAL RESEARCH, 1995, 28 (02) :101-111

[8] Optimized DNA targeting using N,N-bis(2-pyridylmethyl)-β-alanyl 2′-amino-LNA [J].

Babu, BR ;

Hrdlicka, PJ ;

McKenzie, CJ ;

Wengel, J .

CHEMICAL COMMUNICATIONS, 2005, (13) :1705-1707

[9] Chemical Modification of siRNAs for In Vivo Use [J].

Behlke, Mark A. .

OLIGONUCLEOTIDES, 2008, 18 (04) :305-319

[10] The promises and pitfalls of RNA-interference-based therapeutics [J].

Castanotto, Daniela ;

Rossi, John J. .

NATURE, 2009, 457 (7228) :426-433

← 1 2 3 4 5 6 7 8 9 10 →