GES-13, a β-Lactamase Variant Possessing Lys-104 and Asn-170 in Pseudomonas aeruginosa

被引：17

作者：

Kotsakis, S. D. ^{[1
]}

Papagiannitsis, C. C. ^{[1
]}

Tzelepi, E. ^{[1
]}

Legakis, N. J. ^{[2
]}

Miriagou, V. ^{[1
]}

Tzouvelekis, L. S. ^{[1
,3
]}

机构：

[1] Hellenic Pasteur Inst, Bacteriol Lab, Athens 11521, Greece

[2] Evgenid Gen Hosp, Lab Biopathol, Athens, Greece

[3] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 03期

关键词：

KLEBSIELLA-PNEUMONIAE; MOLECULAR CHARACTERIZATION;

D O I：

10.1128/AAC.01561-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

GES-13 beta-lactamase, a novel GES variant possessing Lys-104 and Asn-170, was identified in Pseudomonas aeruginosa. bla(GES-13) was the single gene cassette of a class 1 integron probably located in the chromosome. GES-13 efficiently hydrolyzed broad-spectrum cephalosporins and aztreonam. Imipenem was a potent inhibitor of GES-13 but was not hydrolyzed at measurable rates.

引用

页码：1331 / 1333

页数：3

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