An integrative approach for the identification of quantitative trait loci

被引：16

作者：

Arbilly, M.

Pisanté, A.

Devor, M.

Darvasi, A. ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Dept Genet, Inst Life Sci, IL-91904 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Dept Cell & Anim Biol, Inst Life Sci, IL-91904 Jerusalem, Israel

来源：

ANIMAL GENETICS | 2006年 / 37卷

关键词：

complex traits; gene mapping; quantitative trait loci;

D O I：

10.1111/j.1365-2052.2006.01472.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

The genetic dissection of complex traits is one of the most difficult and most important challenges facing science today. We discuss here an integrative approach to quantitative trait loci (QTL) mapping in mice. This approach makes use of the wealth of genetic tools available in mice, as well as the recent advances in genome sequence data already available for a number of inbred mouse strains. We have developed mapping strategies that allow a stepwise narrowing of a QTL mapping interval, prioritizing candidate genes for further analysis with the potential of identifying the most probable candidate gene for the given trait. This approach integrates traditional mapping tools, fine mapping tools, sequence-based analysis, bioinformatics and gene expression.

引用

页码：7 / 9

页数：3

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