Preclinical and clinical progress of particle-mediated DNA vaccines for infectious diseases

被引：114

作者：

Fuller, Deborah H.

Loudon, Peter

Schmaljohn, Connie

机构：

[1] Univ Pittsburgh, Sch Med, Dept Mol Genet & Biochem, Pittsburgh, PA 15238 USA

[2] PowderMed Ltd, Oxford OX4 4GA, England

[3] USA, Med Res Inst Infect Dis, Ft Detrick, MD 21702 USA

来源：

METHODS | 2006年 / 40卷 / 01期

关键词：

DNA vaccine; particle; mediated epidermal delivery; gene gun; nonhuman primate; swine; human clinical trial;

D O I：

10.1016/j.ymeth.2006.05.022

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This review provides an overview of studies employing particle-mediated epidermal delivery (PMED) or the gene gun to administer DNA vaccines for infectious diseases in preclinical studies employing large animal models and in human clinical trials. It reviews the immunogenicity and protective efficacy of PMED DNA vaccines in nonhuman primates and swine and studies that have directly compared the effectiveness of PMED in these large animal models to existing licensed vaccines and intramuscular or intradermal delivery of DNA vaccines with a needle. Various clinical trials employing PMED have been completed and an overview of the immunogenicity, safety, and tolerability of this approach in humans is described. Finally, efforts currently in progress for commercial development of particle-mediated DNA vaccines are discussed. (c) 2006 Elsevier Inc. All rights reserved.

引用

收藏

页码：86 / 97

页数：12

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