Biocatalysis for industrial production of fine chemicals

被引：180

作者：

Schulze, B

Wubbolts, MG

机构：

[1] DSM Res BV, NL-6160 MD Geleen, Netherlands

[2] DSM Biotech GmbH, D-52428 Julich, Germany

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 1999年 / 10卷 / 06期

关键词：

D O I：

10.1016/S0958-1669(99)00042-7

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Chiral intermediates constitute a significant part of the fine chemicals market, which is strongly influenced by trends in the pharmaceutical industries, where similar to 70% of pharmaceuticals are expected to be enantiomerically pure in the next century as compared to 25% today. The main technologies by which enantiomerically pure ingredients are obtained today are (dynamic) resolutions of racemic mixtures. Asymmetric syntheses are being developed, but their applications in industry are still under represented. Biotechnological methods, resolutions as well as asymmetric syntheses, are becoming increasingly important in the industrial production of fine chemicals.

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收藏

页码：609 / 615

页数：7

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