Nankakurine A, a novel C16N2-type alkaloid from Lycopodium hamiltonii

被引：43

作者：

Hirasawa, Y ^{[1
]}

Morita, H ^{[1
]}

Kobayashi, J ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Kita Ku, Sapporo, Hokkaido 0600812, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 19期

关键词：

D O I：

10.1021/ol048621a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, fused-tetracyclic Lycopodium alkaloid, nankakurine A (1), consisting of a cyclohexane ring and a 3-aza-bicyclo[3.3.1]nonane ring connected to a piperidine ring through a spiro carbon, was isolated from the club moss Lycopodium hamiltonii. The structure and relative stereochemistry were elucidated on the basis of spectroscopic data.

引用

页码：3389 / 3391

页数：3

共 36 条

[21]

KOBAYASHI J, ALKALOIDS, V61

[22] Chemistry, pharmacology, and clinical efficacy of the Chinese nootropic agent huperzine A [J].

Kozikowski, AP ;

Tückmantel, W .

ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (08) :641-650

[23] AN IMPROVED SYNTHETIC ROUTE TO HUPERZINE-A - NEW ANALOGS AND THEIR INHIBITION OF ACETYLCHOLINESTERASE [J].

KOZIKOWSKI, AP ;

CAMPIANI, G ;

AAGAARD, P ;

MCKINNEY, M .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1993, (10) :860-862

[24] THE STRUCTURES OF HUPERZINE-A AND HUPERZINE-B, 2 NEW ALKALOIDS EXHIBITING MARKED ANTICHOLINESTERASE ACTIVITY [J].

LIU, JS ;

ZHU, YL ;

YU, CM ;

ZHOU, YZ ;

HAN, YY ;

WU, FW ;

QI, BF .

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 1986, 64 (04) :837-839

[25]

MacLean DB., 1985, ALKALOIDS, V26, P241, DOI DOI 10.1016/S0099-9598(08)60196-0

[26]

MACLEAN DB, 1973, ALKALOIDS, V14, P348

[27]

MacLean DB., 1968, ALKALOIDS, V10, P305, DOI DOI 10.1016/S1876-0813(08)60256-0

[28] New phlegmarane-type, cernuane-type, and quinolizidine alkaloids from two species of Lycopodium [J].

Morita, H ;

Hirasawa, Y ;

Shinzato, T ;

Kobayashi, J .

TETRAHEDRON, 2004, 60 (33) :7015-7023

[29] Himeradine A, a novel C27N3-type alkaloid from Lycopodium chinense [J].

Morita, H ;

Hirasawa, Y ;

Kobayashi, J .

JOURNAL OF ORGANIC CHEMISTRY, 2003, 68 (11) :4563-4566

[30] Serratezomines A-C, new alkaloids from Lycopodium serratum var. serratum [J].

Morita, H ;

Arisaka, M ;

Yoshida, N ;

Kobayashi, J .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (19) :6241-6245

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