Studies toward the synthesis of salinosporamide A, a potent proteasome inhibitor

被引：23

作者：

Caubert, Virginie ^{[1
]}

Langlois, Nicole ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 26期

关键词：

protease inhibitor; salinosporamide A; pyroglutamate; 1,3-dipolar cycloadditions; diazomethane; N-methylnitrone; samarium diiodide;

D O I：

10.1016/j.tetlet.2006.04.070

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alpha-methylenepyrrolidinone bearing all the functionalities and relative configurations of an advanced intermediate in the synthesis of salinosporamide A and analogues has been synthesized front methyl pyroglutamate through regio- and stereoselective N-methylnitrone cycloaddition. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4473 / 4475

页数：3

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