The promise of comparative genomics in mammals

被引：398

作者：

O'Brien, SJ ^{[1
]}

Menotti-Raymond, M

Murphy, WJ

Nash, WG

Wienberg, J

Stanyon, R

Copeland, NG

Jenkins, NA

Womack, JE

Graves, JAM

机构：

[1] NCI, Lab Genom Divers, Frederick, MD 21702 USA

[2] NCI, Mammalian Genet Lab, Adv Biosci Labs, Frederick, MD 21702 USA

[3] Texas A&M Univ, Coll Vet Med, Dept Vet Pathol, College Stn, TX 77843 USA

[4] La Trobe Univ, Dept Genet & Evolut, Melbourne, Vic 3083, Australia

来源：

SCIENCE | 1999年 / 286卷 / 5439期

关键词：

D O I：

10.1126/science.286.5439.458

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of Livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.

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页码：458 / +

页数：8

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