Silica nanoparticles as a delivery system for nucleic acid-based reagents

被引：67

作者：

Hom, Christopher ^{[1
]}

Lu, Jie ^{[1
]}

Tamanoi, Fuyuhiko ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Calif NanoSyst Inst, Dept Microbiol Mol Genet & Immunol, JCCC, Los Angeles, CA 90095 USA

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2009年 / 19卷 / 35期

关键词：

VIVO GENTAMICIN RELEASE; MESENCHYMAL STEM-CELLS; MESOPOROUS SILICA; GENE DELIVERY; DNA DELIVERY; IN-VIVO; GROWTH-FACTOR; ANTISENSE OLIGONUCLEOTIDES; DRUG-DELIVERY; TRANSFECTION EFFICIENCY;

D O I：

10.1039/b904197d

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The transport of nucleic acid-based reagents is predicated upon developing structurally stable delivery systems that can preferentially bind and protect DNA and RNA, and release their cargo upon reaching their designated sites. Recent advancements in tailoring the size, shape, and external surface functionalization of silica materials have led to increased biocompatibility and efficiency of delivery. In this Feature Article, we highlight recent research progress in the use of silica nanoparticles as a delivery vehicle for nucleic acid-based reagents.

引用

页码：6308 / 6316

页数：9

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