Strecker reaction of aldimines catalyzed by a nucleophilic N-heterocyclic carbene

被引：30

作者：

Fukuda, Yoshimasa ^{[1
]}

Maeda, Yuka ^{[1
]}

Kondo, Kazuhiro ^{[1
]}

Aoyama, Toyohiko ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

SYNTHESIS-STUTTGART | 2006年 / 12卷 / 12期

关键词：

Strecker reaction; aldimine; N-heterocyclic carbene; imidazolium salt; cyanation;

D O I：

10.1055/s-2006-942376

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first method for Strecker reaction (cyanation of imines) of aldimines with TMSCN in the presence of N-heterocyclic carbene prepared from 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride and t-BuOK, as a nucleophilic catalyst, is described.

引用

页码：1937 / 1939

页数：3

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