A practical stereoselective synthesis of both enantiomers of threo- and erythro-β-hydroxy norvaline from (S)-serine derivatives

被引：18

作者：

Andrés, JM ^{[1
]}

de Elena, N ^{[1
]}

Pedrosa, R ^{[1
]}

机构：

[1] Univ Valladolid, Fac Ciencias, Dept Quim Organ, E-47011 Valladolid, Spain

来源：

TETRAHEDRON | 2000年 / 56卷 / 11期

关键词：

diastereoselective synthesis; aminoalcohols; alkylzincs; aminoaldehydes;

D O I：

10.1016/S0040-4020(00)00038-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The four enantiopure diastereoisomers of beta-hydroxy norvaline have been prepared from L-serine in moderate chemical yield. The method is based on the diastereoselective addition of different organometallics to easily accessible serinal derivatives. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1523 / 1531

页数：9

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