Microwave-assisted natural product chemistry

被引:20
作者
Appukkuttan, Prasad
Van der Eycken, Erik
机构
[1] Uppsala Univ, BMC, Dept Med Chem, SE-75123 Uppsala, Sweden
[2] Katholieke Univ Leuven, Dept Chem, B-3001 Louvain, Belgium
来源
MICROWAVE METHODS IN ORGANIC SYNTHESIS | 2006年 / 266卷
关键词
alkaloids; microwave irradiation; natural products; steroids; total synthesis;
D O I
10.1007/128_051
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
An overview of the application of microwave irradiation in natural product synthesis is presented, focusing on the developments in the last 5-10 years. This contribution covers the literature concerning the total synthesis of natural products and their analogues, the synthesis of alkaloids and the construction of building blocks of interest for natural product synthesis. As microwave irradiation appeared on the scene only recently, we are at an early stage of its application in natural product chemistry, even though some nice examples have been communicated recently. The application of dedicated microwave instruments as well as domestic microwave ovens is discussed, giving emphasis to the microwave-enhanced transformations.
引用
收藏
页码:1 / 47
页数:47
相关论文
共 195 条
  • [71] ANTIMALARIAL ACTIVITY OF PARTHENIN AND ITS DERIVATIVES
    HOOPER, M
    KIRBY, GC
    KULKARNI, MM
    KULKARNI, SN
    NAGASAMPAGI, BA
    ONEILL, MJ
    PHILLIPSON, JD
    ROJATKAR, SR
    WARHURST, DC
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1990, 25 (09) : 717 - 723
  • [72] A facile synthsis of 1,1-disubstituted 1,2,3,4-tetrahydro-β-carbolines via trifluoroacetic acid catalyzed Pictet-Spengler reaction using titanium(IV) isopropoxide as an imination reagent
    Horiguchi, Y
    Nakamura, M
    Kida, A
    Kodama, H
    Saitoh, T
    Sano, T
    [J]. HETEROCYCLES, 2003, 59 (02) : 691 - 705
  • [73] A synthesis of chiral 1,1,3-trisubstituted 1,2,3,4-tetrahydro-β-carbolines by the Pictet-Spengler reaction of tryptophan and ketones:: Conversion of (1R,3S)-diastereomers into their (1S,3S)-counterparts by scission of the C(1)-N(2) bond
    Horiguchi, Y
    Nakamura, M
    Saitoh, T
    Sano, T
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2003, 51 (12) : 1368 - 1373
  • [74] A convenient synthesis of 1,1-disubstituted 1,2,3,4-tetrahydroisoquinolines via Pictet-Spengler reaction using titanium(IV) isopropoxide and acetic-formic anhydride
    Horiguchi, Y
    Kodama, H
    Nakamura, M
    Yoshimura, T
    Hanezi, K
    Hamada, H
    Saitoh, T
    Sano, T
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2002, 50 (02) : 253 - 257
  • [75] ISHIDA Y, 1983, J PHARMACOBIO-DYNAM, V6, P391
  • [76] ISHIDA Y, 1985, J PHARMACOBIO-DYNAM, V8, P917
  • [77] The synthesis of phycopsisenone, a new phenolic secondary metabolite from the sponge Phycopsis sp.
    Kad, GL
    Singh, V
    Khurana, A
    Singh, J
    [J]. JOURNAL OF NATURAL PRODUCTS, 1998, 61 (02): : 297 - 298
  • [78] Total synthesis of the highly potent anti-HIV natural product daurichromenic acid along with its two chromane derivatives, rhododaurichromanic acids A and B
    Kang, Y
    Mei, Y
    Du, YG
    Jin, ZD
    [J]. ORGANIC LETTERS, 2003, 5 (23) : 4481 - 4484
  • [79] The impact of microwave synthesis on drug discovery
    Kappe, CO
    Dallinger, D
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (01) : 51 - 63
  • [80] Controlled microwave heating in modern organic synthesis
    Kappe, CO
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (46) : 6250 - 6284