Investigation of ionic liquids as reaction media for enzymatic enantioselective acylation of amines

被引：72

作者：

Irimescu, R ^{[1
]}

Kato, K ^{[1
]}

机构：

[1] AIST, Biofunct Ceram Grp, Ceram Res Inst, Moriyama Ku, 2266-98 Anagahora, Nagoya, Aichi 4638560, Japan

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2004年 / 30卷 / 5-6期

基金：

日本学术振兴会;

关键词：

enantioselective amine acylation; ionic liquids; lipase; 4-pentenoic acid; solvent properties;

D O I：

10.1016/j.molcatb.2004.05.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of ionic liquids as reaction media for lipase-catalyzed enantioselective acylation of 1-phenylethylamine (1) and 2-phenyl-1-propylamine (2) with 4-pentenoic acid was investigated. The best performing ionic liquid for each of these amines as well as its solvent properties were very different. Preparative scale kinetic resolution of 1 was performed efficiently in 1-butyl-2,3-dimethylimidazolium trifluoromethanesulphonate. (C) 2004 Elsevier B.V. All rights reserved.

引用

收藏

页码：189 / 194

页数：6

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